Negotiations on financial agreements are based on final financial estimates. Campillo-Artero C, Kovacs F. The use of risk-sharing instruments for the monitoring of non-pharmacological technology after introduction into routine practice: results after one year. BMC Health Serv Res. 2013;13:181. doi.org/10.1186/1472-6963-13-181. Yu JS, Chin L, Oh J, Farias J. Performance-based risk-sharing arrangements for pharmaceutical products in the United States: a systematic review. J Manag Care Spec Pharm. 2017;23 (10):1028-40.

Garattini L, Curto A, Van de Vooren K. Italian drug risk-sharing agreements: do they pay off? Eur J Health Econ. 2015;16:1-3. Makady A, van Veelen A, de Boer A, Hillege H, Klungel OH, Goettsch W. Putting managed entry agreements into practice: the control of Dutch reality. Health policy. 2019;123(3):267–74. The current scene of performance and risk-sharing agreements in the Spanish region of Catalonia. Expert Rev Pharmacoecon Outcomes Res.

2019. doi.org/10.1080/14737167.2019.1587296. Mahjoub R, Ødegaard F, Zaric GS. Evaluation of a pharmaceutical risk-sharing agreement when patients are evaluated to determine the likelihood of success. Health Econ. 2018; 27 (1): e15-25. Over the past 20 years, the use of risk-sharing agreements has increased dramatically (described in the section “Drug Pricing and Reimbursement”, “How are drug prices set? What is the relationship between pricing and reimbursement? “above) to establish a difference between the published price of a medicinal product (the PMA) and the actual price paid by the Commonwealth for that medicinal product. According to these documents, the difference between the published prize and the actual price represents discounts that the sponsor pays to the Commonwealth. Almost all expensive drugs are now included in the schedule with a confidential risk-sharing agreement. The reaction of the industry and the Commonwealth has been the conclusion of agreements in which the industry agrees to the introduction of certain price control measures, in exchange for the Commonwealth`s promise of a certain degree of political security and consultation and an appropriate procedure with regard to future policy changes.

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