Cede decisions for JHM/JHHS are made based on the study, so a Reliance Request Survey must be presented. If JHM/JHS agrees: For all federally funded research and, if possible, for all other research, the Office of Human Subjects Research requires that the SMART IRB Master Common Common Reciprocal Institutional Review Authorization Agreement be used as a dependency base for all studies in which JHM serves as sIRB. In accordance with the requirements of the NIH POLITIC and the revised common rule, JHM will review IRB applications to serve as a sIRB for all research studies on publicly funded, cooperative and unhasted human issues conducted in the United States. For studies submitted to the NIH sIRB Directive, where a website participating in a site study has granted a waiver to the IRB verification requirement, it should be considered that the participating website will receive its own local IRB verification/designation. A reliability agreement would not be executed with this site. JHM/JHHS` preference is to use the “SMART IRB Acknowledgement Letter of Acknowledgement” [LOA] to document addiction. Signature lines are not necessary, but can be added if necessary [z.B. at the request of the trust institution]. JHM IRB will review IIRB applications as well as applications for an external BRI. As a general rule, applications for confidence are submitted to our IRB on two dates: reliance agreements can cover a particular project or a wide range of projects. If JHM IRB is the IRB audit, participating websites are required to fully execute a reliability agreement with JHM IRB before the search can begin on the participating site. If jHHS is the trusted organization, a withdrawal decision must be finalized and the local context review must be completed by JHM HRPP before a search can begin at the JHS/JHS sites.

Even after external sIRB approval, no human research should begin at CHOP until a number of steps have been completed. In order for chop to accept the audit at the SIRB, chop IRB must confirm that the approval form complies with CHOP requirements, that CHOP auxiliary commissions must review and approve the study – the IBC committee, conflicts of interest, etc. – and that the institutional (or delegated) staff must sign the agreement. All applications for trust agreements must be submitted through the Reliance Request survey. The information gathered in the application allows the JIM IRB trust team to make a first provision of the CEDE (for example. B if JHM agrees to serve as a single IRB or to rely on an external IRB). JHM`s IRB auditors cannot require JHM IRB to serve as an SRRR without prior authorization [for example. B a letter of support] and they also do not have the authority to rely on an external IRB INTELLIGENT IRB on behalf of the organization: the “SMART IRB” master`s reliance agreement was created in 2016 to harmonize and streamline the IRB verification process for multi-site studies. It makes it possible to depend on the basis of the study, clearly defines the roles and responsibilities of trusted institutions and verifies RB and eliminates the need to sign dependency agreements for each study [z.B a non-SMART IRB agreement]. More than 500 institutions have already signed this agreement and actively use it as a base for dependence on multi-site projects.